KPV (also known as Lysine-Proline-Valine, α-MSH 11-13) is a short tripeptide fragment of α-MSH studied for anti-inflammatory effects. This page covers what the published research does — and does not — establish about it in relation to gut health and digestive repair.
KPV is researched for Gut inflammation, Skin inflammation — which is why it appears in discussions of gut health and digestive repair.
Research status: Preclinical research in inflammation models.
How KPV is thought to work
KPV is the C-terminal tripeptide (lysine-proline-valine) of the hormone α-MSH. Research suggests it carries much of α-MSH's anti-inflammatory activity — potentially acting inside cells to dampen inflammatory signaling — which is why it is studied in gut and skin inflammation models.
What it does not establish
Human clinical data is limited. Studied mostly in cell and animal models.
Nothing on this page is a recommendation to use KPV, and Selpho publishes no dosing, reconstitution or sourcing information. Read how we decide what goes in the library.
Commonly researched alongside
Other peptides researched for Gut Health
The human cathelicidin antimicrobial peptide studied for immune defense.
Frequently asked questions
Preclinical research in inflammation models. Research relevant to this area covers gut inflammation, skin inflammation. That is a description of where the research points, not evidence that it will work for you — and Selpho does not provide dosing or medical advice.
Preclinical research in inflammation models.
Human clinical data is limited. Studied mostly in cell and animal models. Always speak to a licensed healthcare professional before considering any peptide.
Anti-inflammatory effects, particularly in the gastrointestinal tract and skin, plus general immune modulation. Evidence is mostly preclinical.
No. KPV is a small peptide fragment of α-MSH, not a corticosteroid. It is studied for anti-inflammatory activity through different pathways.
Is KPV right for your situation?
Describe your goals and the free Peptide Advisor will match them against the research — no signup, no sales pitch.
Ask the Advisor — freeThis page is for educational purposes only and is not medical advice, a diagnosis, or a recommendation to use any compound. It contains no dosing or purchase information. Always consult a licensed healthcare professional before considering any peptide.