KPV (also known as Lysine-Proline-Valine, α-MSH 11-13) is a short tripeptide fragment of α-MSH studied for anti-inflammatory effects. This page covers what the published research does — and does not — establish about it in relation to joint, tendon and ligament recovery.
KPV is discussed in the context of joint, tendon and ligament recovery because of its mechanism, not because the literature studies it for that outcome directly. The research we can point to covers Gut inflammation, Skin inflammation, Immune modulation. Treat any claim beyond that with scepticism.
Research status: Preclinical research in inflammation models.
How KPV is thought to work
KPV is the C-terminal tripeptide (lysine-proline-valine) of the hormone α-MSH. Research suggests it carries much of α-MSH's anti-inflammatory activity — potentially acting inside cells to dampen inflammatory signaling — which is why it is studied in gut and skin inflammation models.
What it does not establish
Human clinical data is limited. Studied mostly in cell and animal models.
Nothing on this page is a recommendation to use KPV, and Selpho publishes no dosing, reconstitution or sourcing information. Read how we decide what goes in the library.
Commonly researched alongside
Other peptides researched for Joint & Tendon Repair
A synthetic peptide widely studied for tissue repair and gut health.
A fragment related to Thymosin Beta-4 studied for recovery and flexibility.
A copper-binding tripeptide extensively studied in skin and hair research.
Frequently asked questions
Not directly. KPV is discussed in the context of joint, tendon and ligament recovery because of its mechanism, but the research we can point to studies it for gut inflammation, skin inflammation, immune modulation rather than for this outcome specifically. Preclinical research in inflammation models. Selpho does not provide dosing or medical advice.
Preclinical research in inflammation models.
Human clinical data is limited. Studied mostly in cell and animal models. Always speak to a licensed healthcare professional before considering any peptide.
Anti-inflammatory effects, particularly in the gastrointestinal tract and skin, plus general immune modulation. Evidence is mostly preclinical.
No. KPV is a small peptide fragment of α-MSH, not a corticosteroid. It is studied for anti-inflammatory activity through different pathways.
Is KPV right for your situation?
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Ask the Advisor — freeThis page is for educational purposes only and is not medical advice, a diagnosis, or a recommendation to use any compound. It contains no dosing or purchase information. Always consult a licensed healthcare professional before considering any peptide.