TB-500 (also known as Thymosin Beta-4 fragment, TB4) is a fragment related to Thymosin Beta-4 studied for recovery and flexibility. This page covers what the published research does — and does not — establish about it in relation to joint, tendon and ligament recovery.
TB-500 is researched for Muscle & joint recovery, Wound healing — which is why it appears in discussions of joint, tendon and ligament recovery.
Research status: Preclinical research; parent protein (TB4) studied in some human trials.
How TB-500 is thought to work
TB-500 corresponds to an active region of Thymosin Beta-4, a naturally occurring protein that regulates actin, a protein central to cell structure and movement. By influencing cell migration and blood-vessel formation, TB-500 is studied for its potential role in wound healing, flexibility, and muscle and joint recovery.
What it does not establish
Primarily studied in animal models. Human data on the TB-500 fragment specifically is limited.
Nothing on this page is a recommendation to use TB-500, and Selpho publishes no dosing, reconstitution or sourcing information. Read how we decide what goes in the library.
Commonly researched alongside
Other peptides researched for Joint & Tendon Repair
A synthetic peptide widely studied for tissue repair and gut health.
A copper-binding tripeptide extensively studied in skin and hair research.
A short tripeptide fragment of α-MSH studied for anti-inflammatory effects.
Frequently asked questions
Preclinical research; parent protein (TB4) studied in some human trials. Research relevant to this area covers muscle & joint recovery, wound healing. That is a description of where the research points, not evidence that it will work for you — and Selpho does not provide dosing or medical advice.
Preclinical research; parent protein (TB4) studied in some human trials.
Primarily studied in animal models. Human data on the TB-500 fragment specifically is limited. Always speak to a licensed healthcare professional before considering any peptide.
Recovery-related outcomes: muscle and joint repair, flexibility, wound healing, and some cardiac-tissue studies. Much of the evidence is preclinical.
TB-500 is a synthetic fragment representing an active portion of the full Thymosin Beta-4 protein. Human data specifically on the TB-500 fragment is limited.
Is TB-500 right for your situation?
Describe your goals and the free Peptide Advisor will match them against the research — no signup, no sales pitch.
Ask the Advisor — freeThis page is for educational purposes only and is not medical advice, a diagnosis, or a recommendation to use any compound. It contains no dosing or purchase information. Always consult a licensed healthcare professional before considering any peptide.