MK-677 (also known as Ibutamoren, Ibutamoren mesylate) is an orally active growth-hormone secretagogue (a non-peptide) studied for GH/IGF-1. This page covers what the published research does — and does not — establish about it in relation to growth-hormone support.
MK-677 is researched for Growth hormone & IGF-1 — which is why it appears in discussions of growth-hormone support.
Research status: Investigated in human trials; not approved for these uses.
How MK-677 is thought to work
MK-677 (ibutamoren) is an orally active, long-acting growth-hormone secretagogue. Although technically a non-peptide, it is grouped with GH peptides because it mimics ghrelin to raise growth hormone and IGF-1 levels.
What it does not establish
Can increase appetite, water retention and blood sugar. Technically a non-peptide secretagogue.
Nothing on this page is a recommendation to use MK-677, and Selpho publishes no dosing, reconstitution or sourcing information. Read how we decide what goes in the library.
Other peptides researched for Growth Hormone
A growth-hormone-releasing hormone analog studied for GH support.
A selective growth-hormone secretagogue studied for its clean GH-release profile.
One of the earliest GHRH analogs, historically used to assess GH function.
A GHRH analog approved for HIV-associated lipodystrophy and studied for visceral fat.
An early GH-releasing peptide known for strongly stimulating appetite.
A potent GH secretagogue also studied for cardiac tissue effects.
Frequently asked questions
Investigated in human trials; not approved for these uses. Research relevant to this area covers growth hormone & igf-1. That is a description of where the research points, not evidence that it will work for you — and Selpho does not provide dosing or medical advice.
Investigated in human trials; not approved for these uses.
Can increase appetite, water retention and blood sugar. Technically a non-peptide secretagogue. Always speak to a licensed healthcare professional before considering any peptide.
Not exactly — it is a non-peptide secretagogue, but it is commonly grouped with GH peptides because it raises GH and IGF-1 by mimicking ghrelin.
Growth hormone and IGF-1 levels, sleep, body composition, and bone density. It has been investigated in human trials.
Is MK-677 right for your situation?
Describe your goals and the free Peptide Advisor will match them against the research — no signup, no sales pitch.
Ask the Advisor — freeThis page is for educational purposes only and is not medical advice, a diagnosis, or a recommendation to use any compound. It contains no dosing or purchase information. Always consult a licensed healthcare professional before considering any peptide.