What is MOTS-c?
MOTS-c is a peptide encoded in mitochondrial DNA that acts as a metabolic regulator. Research has explored its role in insulin sensitivity, metabolic homeostasis and exercise capacity.
Also known as: Mitochondrial ORF of the 12S rRNA type-c
How MOTS-c is studied
MOTS-c is a peptide encoded within mitochondrial DNA that acts as a metabolic regulator, influencing insulin sensitivity and energy homeostasis — partly through AMPK, a key cellular energy sensor. It is studied for metabolic health and exercise capacity.
Commonly researched for
Research status
Important considerations
Mostly studied in animal and cell models. Human data is emerging.
MOTS-c — frequently asked questions
Insulin sensitivity, metabolic health, and exercise/endurance, mostly in animal and cell models with emerging human interest.
It is a mitochondrial-derived peptide — encoded by mitochondrial rather than nuclear DNA — which is a relatively new area of biology.
Human data is early. Most evidence is preclinical, so effects and safety in people are not established.