MOTS-c (also known as Mitochondrial ORF of the 12S rRNA type-c) is a mitochondrial-derived peptide studied for metabolism and exercise. This page covers what the published research does — and does not — establish about it in relation to anti-aging and longevity.
MOTS-c is discussed in the context of anti-aging and longevity because of its mechanism, not because the literature studies it for that outcome directly. The research we can point to covers Insulin sensitivity, Metabolic health, Exercise & endurance. Treat any claim beyond that with scepticism.
Research status: Preclinical research; early human interest.
How MOTS-c is thought to work
MOTS-c is a peptide encoded within mitochondrial DNA that acts as a metabolic regulator, influencing insulin sensitivity and energy homeostasis — partly through AMPK, a key cellular energy sensor. It is studied for metabolic health and exercise capacity.
What it does not establish
Mostly studied in animal and cell models. Human data is emerging.
Nothing on this page is a recommendation to use MOTS-c, and Selpho publishes no dosing, reconstitution or sourcing information. Read how we decide what goes in the library.
Other peptides researched for Anti-Aging
A mitochondrial-derived peptide studied for cytoprotection and aging.
A mitochondria-targeting peptide studied for cellular energy and disease.
A copper-binding tripeptide extensively studied in skin and hair research.
Frequently asked questions
Not directly. MOTS-c is discussed in the context of anti-aging and longevity because of its mechanism, but the research we can point to studies it for insulin sensitivity, metabolic health, exercise & endurance rather than for this outcome specifically. Preclinical research; early human interest. Selpho does not provide dosing or medical advice.
Preclinical research; early human interest.
Mostly studied in animal and cell models. Human data is emerging. Always speak to a licensed healthcare professional before considering any peptide.
Insulin sensitivity, metabolic health, and exercise/endurance, mostly in animal and cell models with emerging human interest.
It is a mitochondrial-derived peptide — encoded by mitochondrial rather than nuclear DNA — which is a relatively new area of biology.
Is MOTS-c right for your situation?
Describe your goals and the free Peptide Advisor will match them against the research — no signup, no sales pitch.
Ask the Advisor — freeThis page is for educational purposes only and is not medical advice, a diagnosis, or a recommendation to use any compound. It contains no dosing or purchase information. Always consult a licensed healthcare professional before considering any peptide.